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Genomic structures of human type I and II TNF receptors: Implications for protein structure and evolutionary history


Book ID
122606721
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
183 KB
Volume
3
Category
Article
ISSN
1043-4666

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Transforming growth factor-b (TGF-b1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investi