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Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein

✍ Scribed by Atsushi Miyahara; Yuko Okamura-Oho; Toshiyuki Miyashita; Akinori Hoshika; Masao Yamada


Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
500 KB
Volume
48
Category
Article
ISSN
1435-232X

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pp120, a substrate of the insulin receptor tyrosine kinase, is a plasma membrane glycoprotein in the hepatocyte. It is expressed as two spliced isoforms differing by the presence (full length) or absence (truncated) of most of the intracellular domain including all phosphorylation sites. Because the