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Genomic rearrangements in MSH2 and MLH1 are rare mutational events in Spanish patients with hereditary nonpolyposis colorectal cancer

✍ Scribed by Sergi Castellví-Bel; Antoni Castells; Mark Strunk; Ángel Ferrández; Elena Piazuelo; Montserrat Milà; Virgínia Piñol; Francisco Rodríguez-Moranta; Montserrat Andreu; Ángel Lanas; Josep Maria Piqué; The Gastrointestinal Oncology Group of the Spanish Gastroenterological Association


Book ID
116333605
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
264 KB
Volume
225
Category
Article
ISSN
0304-3835

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## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysis, point mutations in the DNA mismatch repair genes __MSH2__ and __MLH1__ have been detected in up to 64% of patients suspected of H