Genomic rearrangements in MSH2 and MLH1 are rare mutational events in Spanish patients with hereditary nonpolyposis colorectal cancer
✍ Scribed by Sergi Castellví-Bel; Antoni Castells; Mark Strunk; Ángel Ferrández; Elena Piazuelo; Montserrat Milà; Virgínia Piñol; Francisco Rodríguez-Moranta; Montserrat Andreu; Ángel Lanas; Josep Maria Piqué; The Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
- Book ID
- 116333605
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 264 KB
- Volume
- 225
- Category
- Article
- ISSN
- 0304-3835
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📜 SIMILAR VOLUMES
Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred
## Abstract Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysis, point mutations in the DNA mismatch repair genes __MSH2__ and __MLH1__ have been detected in up to 64% of patients suspected of H