Anaplastic large cell lymphoma (ALCL) comprises a group of non-Hodgkin lymphomas characterized by the expression of the CD30/Ki-1 antigen. A subset of ALCL is characterized by chromosomal translocations involving the anaplastic lymphoma kinase (ALK) gene on chromosome 2. While the most common transl
✦ LIBER ✦
Genomic profiling reveals different genetic aberrations in systemic ALK-positive and ALK-negative anaplastic large cell lymphomas
✍ Scribed by Itziar Salaverria; Silvia Beà; Armando Lopez-Guillermo; Virginia Lespinet; Magda Pinyol; Birgit Burkhardt; Laurence Lamant; Andreas Zettl; Doug Horsman; Randy Gascoyne; German Ott; Reiner Siebert; Georges Delsol; Elias Campo
- Book ID
- 108675544
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 341 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0007-1048
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## Abstract Anaplastic lymphoma kinase (ALK)‐positive anaplastic large cell lymphoma (ALCL) is a T‐cell malignancy in which ALK expression is a consequence of the t(2;5) or a variant translocation involving Chromosome 2. For the most part, this disease presents in the pediatric population and most,
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