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Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles

✍ Scribed by Loudin, M G; Wang, J; Eastwood Leung, H-C; Gurusiddappa, S; Meyer, J; Condos, G; Morrison, D; Tsimelzon, A; Devidas, M; Heerema, N A; Carroll, A J; Plon, S E; Hunger, S P; Basso, G; Pession, A; Bhojwani, D; Carroll, W L; Rabin, K R

Book ID: 120260913
Publisher: Nature Publishing Group
Year: 2011
Tongue: English
Weight: 511 KB
Volume: 25
Category: Article
ISSN: 0887-6924
DOI: 10.1038/leu.2011.128

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Genomic profiling in Down syndrome acute

Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles

✍ Loudin, M G; Wang, J; Eastwood Leung, H-C; Gurusiddappa, S; Meyer, J; Condos, G; 📂 Article 📅 2011 🏛 Nature Publishing Group 🌐 English ⚖ 511 KB

Patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) have distinct clinical and biological features. Whereas most DS-ALL cases lack the sentinel cytogenetic lesions that guide risk assignment in childhood ALL, JAK2 mutations and CRLF2 overexpression are highly enriched. To further