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Genomic predictors of response to doxorubicin versus docetaxel in primary breast cancer

✍ Scribed by M. Martin; A. Romero; M. C. U. Cheang; J. A. López García-Asenjo; J. A. García-Saenz; B. Oliva; J. M. Román; X. He; A. Casado; J. de la Torre; V. Furio; J. Puente; T. Caldés; J. A. Vidart; Sara Lopez-Tarruella; E. Diaz-Rubio; C. M. Perou


Publisher
Springer US
Year
2011
Tongue
English
Weight
296 KB
Volume
128
Category
Article
ISSN
0167-6806

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## Abstract We studied the relationship between response of breast cancer to docetaxel (DOC) or cylophosphamide + epirubucin (CE) treatment and CYP3A4 mRNA expression in breast tumors. CYP3A4 inactivates DOC but not E, which is a predominant effector in CE treatment. Twenty patients with locally ad