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Genomic organization of the mouse B-lymphocyte activation antigen B7

โœ Scribed by Annamalai Selvakumar; Perrin C. White; Bo Dupont


Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
341 KB
Volume
38
Category
Article
ISSN
0093-7711

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โœฆ Synopsis


T-lymphocyte activation and proliferation in vitro requires two signals, one through the occupancy of the T-cell receptor (TcR) by antigenic peptides in association with major histocompatibility antigens and the other through one or more co-stimulatory pathways (Mueller et al. 1989). The interaction of the B-lymphocyte activation antigen B7 and its counter receptor CD28 on T cells has been shown to provide one of these co-stimulatory signals (


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