The generation of an antigen-specific T-cell response requires that the T lymphocyte receive two signals from the antigen presenting cell The specificity of this response is provided by antigen presented to the T lymphocyte and involves stimulation of the T lymphocyte via the T-cell receptor (TCR)/C
Genomic organization of the mouse B-lymphocyte activation antigen B7
โ Scribed by Annamalai Selvakumar; Perrin C. White; Bo Dupont
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 341 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0093-7711
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โฆ Synopsis
T-lymphocyte activation and proliferation in vitro requires two signals, one through the occupancy of the T-cell receptor (TcR) by antigenic peptides in association with major histocompatibility antigens and the other through one or more co-stimulatory pathways (Mueller et al. 1989). The interaction of the B-lymphocyte activation antigen B7 and its counter receptor CD28 on T cells has been shown to provide one of these co-stimulatory signals (
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LMP7 is one of the two proteasome subunits encoded in the major histocompatibility complex and is speculated to play a role in the generation of endogenous peptides for presentation by class I molecules to cytotoxic T cells. Here we report the genomic organization of the mouse Lmp-7 gene and the tis