✦ LIBER ✦

Genomic organization of microRNAs

✍ Scribed by Abigail F. Olena; James G. Patton

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 195 KB
Volume: 222
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21993

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✦ Synopsis

Abstract

microRNAs (miRNAs) are small (∼22 nt) noncoding RNAs that have been shown to regulate gene expression post‐transcriptionally. They function by pairing with the 3′ UTR of target mRNAs and repressing translation or by targeting the mRNA for degradation. miRNAs are involved in diverse aspects of development, maintenance, and disease, and are largely evolutionarily conserved in metazoans. Searching the genomes of organisms from viruses to worms to humans has revealed potentially thousands of miRNA genes. Understanding the patterns of genomic organization between species cannot only help to refine tools to identify new miRNAs, but also provide insight into miRNA biogenesis and function. J. Cell. Physiol. 222: 540–545, 2010. © 2009 Wiley‐Liss, Inc.

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