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Genomic organization and comparative analysis of the mouse tuberous sclerosis 1 (Tsc1) locus

✍ Scribed by Jeremy P. Cheadle, Lorraine Dobbie, Shelley Idziaszczyk, Angela K. Hodges, Andrew J.H. Smith, Julian R. Sampson, Janet Young


Book ID
113034821
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
821 KB
Volume
11
Category
Article
ISSN
0938-8990

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Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development of multiple hamartomas involving many organs. About two-thirds of the cases are sporadic and appear to represent new mutations. With the cloning of two causative genes, TSC1 and TSC2 it is now possibl