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Genomic organization and chromosomal mapping of ELKS, a gene rearranged in a papillary thyroid carcinoma

✍ Scribed by T. Yokota; T. Nakata; S. Minami; J. Inazawa; M. Emi

Book ID
106252380
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
243 KB
Volume
45
Category
Article
ISSN
1435-232X

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Differential expression of multiple isof
Differential expression of multiple isoforms of the ELKS mRNAs involved in a papillary thyroid carcinoma
✍ Tomoko Nakata; Takashi Yokota; Mitsuru Emi; Shiro Minami πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 318 KB

## Abstract A novel gene, __ELKS,__ whose 5β€² portion was fused to the __RET__ gene, was found in a papillary thyroid carcinoma. A cDNA of this gene obtained from a human‐brain cDNA library revealed that it encoded a peptide of 948 amino acids, termed ELKSΞ±. We identified four other isoforms, which

Fusion of a novel gene, ELKS, to RET due
Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma
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In papillary thyroid carcinomas, the genes for receptor-type tyrosine kinase, RET or TRKA, are sometimes rearranged, resulting in fusion of its tyrosine kinase domain to 5Ј portions of several activating genes. In a papillary thyroid carcinoma, we identified a novel gene (ELKS), the 5Ј portion of wh