Genomic Medicine: A Practical Guide

✍ Scribed by Laura J. Tafe, Maria E. Arcila

• Publisher: Springer International Publishing
• Year: 2020
• Tongue: English
• Leaves: 323
• Edition: 1st ed. 2020
• Category: Library

✦ Synopsis

The field of Molecular Diagnostics is rapidly evolving and molecular characterization of neoplasms is becoming an increasingly important part of the pathologic work up and diagnosis of many tumor types. This work provides a high-yield reference book that compiles critical information related to molecular biomarkers for various solid tumor and hematologic malignancy subtypes. It is succinct yet comprehensive enough to be suitable for fellows in training and medical professionals with an interest in molecular pathology and biomarkers. The book covers many aspects of molecular diagnostics, from techniques to applications and comprehensive summaries of the current molecular biomarkers of critical importance in solid and liquid tumors. Attention is also specifi cally devoted to bioinformatics and next generation sequencing, as well as pre-analytical issues that must be considered for accurate interpretation of molecular results in the context of overall patient care.
This text focuses on clinical utility and validity and serves as an “owner’s manual” in Genomic Diagnostics for the practicing pathologist, pathology fellows and residents and other health care providers. Physicians will find this book invaluable as a quick reference for current molecular testing modalities and guidelines, tumor board preparation, deciding which test to order and interpreting genomic laboratory results. In addition, it is an accessible for trainees as a board review preparation reference.

✦ Table of Contents

Front Matter ....Pages i-x
Front Matter ....Pages 1-1
Pre-analytics, Current Testing Technologies, and Limitations of Testing (Alejandro Luiña Contreras, Jose Jasper L. Andal, Raymundo M. Lo, Daphne C. Ang)....Pages 3-23
Next-Generation Sequencing (Alanna J. Church)....Pages 25-40
Cell-Free DNA Testing (Brennan Decker, Lynette M. Sholl)....Pages 41-54
Role of Bioinformatics in Molecular Medicine (Chad Vanderbilt, Sumit Middha)....Pages 55-68
Interpreting Genomic Reports (Alejandro Luiña Contreras)....Pages 69-80
Front Matter ....Pages 81-81
Lung Carcinoma (Maria E. Arcila, Jason C. Chang, Laura J. Tafe)....Pages 83-101
GI Including GIST (Efsevia Vakiani)....Pages 103-122
Breast (Dara S. Ross)....Pages 123-131
Genitourinary Tumors (Marie-Lisa Eich, George J. Netto)....Pages 133-147
Gynecologic Malignancies (Jessica L. Dillon, Laura J. Tafe)....Pages 149-158
Sarcomas (Konstantinos Linos)....Pages 159-182
Salivary Gland Carcinomas (Snjezana Dogan)....Pages 183-195
Sinonasal Carcinomas (Snjezana Dogan)....Pages 197-203
Front Matter ....Pages 205-205
Acute Myeloid Neoplasms (Eric Y. Loo)....Pages 207-233
Chronic Myeloid Neoplasms (Maria E. Arcila, Caleb Ho)....Pages 235-251
Lymphomas (Vignesh Shanmugam, Annette S. Kim)....Pages 253-315
Back Matter ....Pages 317-325

✦ Subjects

Medicine & Public Health; Pathology