Genomic instability and apoptosis are frequent in p53 deficient young mice
β Scribed by Fukasawa, Kenji; Wiener, Francis; Woude, George F Vande; Mai, Sabine
- Book ID
- 110061054
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 746 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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## Abstract The acute apoptotic response to genotoxic carcinogens (AARGC) might be important for controlling the subsequent colonic mutational load and progression through oncogenesis. We have found previously that AARGC is __p53__βdependent with a geneβdosage effect, and that decreased AARGC in __
## Abstract Acute apoptotic response to genotoxic carcinogens (AARGC) might be important for controlling the consequences of mutational load in the colon. It has been shown to occur in parallel with activation of DNA repair mechanisms. Inadequate AARGC might allow development of mutated clones with