Genomic Diversity: Applications in Human Population Genetics

✍ Scribed by S. S. Papiha, S. S. Mastana (auth.), Surinder S. Papiha, Ranjan Deka, Ranajit Chakraborty (eds.)

• Publisher: Springer US
• Year: 1999
• Tongue: English
• Leaves: 245
• Edition: 1
• Category: Library

✦ Synopsis

One of the major themes of human population genetics is assaying genetic variation in human populations. The ultimate goal of this objective is to understand the extent of genetic diversity and the use of this knowledge to reconstruct our evolutionary history. The discipline had undergone a revolutionary transition with the advent of molecular techniques in the 1980s. With this shift, statistical methods have also been developed to perceive the biological and molecular basis of human genetic variation.
Using the new perspectives gained during the above transition, this volume describes the applications of molecular markers spanning the autosomal, Y-chromosomal and mitochondrial genome in the analysis of human diversity in contemporary populations. This is the first reference book of its kind to bring together data from these diverse sets of markers for understanding evolutionary histories and relationships of modern humans in a single volume.

✦ Table of Contents

Front Matter....Pages i-viii
Classical to Molecular Polymorphisms....Pages 1-21
Variability in nDNA, mtDNA, and Proteins....Pages 23-32
Genetic Diversity Among Five Native American Tribes of Colombia....Pages 33-51
Trinucleotide Repeats, Genetic Instability and Variation in the Human Genome....Pages 53-64
Y-Chromosomal DNA Markers....Pages 65-73
On the Genetic Origin of the Turks....Pages 75-82
The Origins of Pakistani Populations....Pages 83-90
The Use of Y-Chromosomal DNA Variation to Investigate Population History....Pages 91-101
A Mitochondrial DNA Database....Pages 103-119
The Trans-Caucasus and the Expansion of the Caucasoid-Specific Human Mitochondrial DNA....Pages 121-133
The Place of the Indian Mitochondrial DNA Variants in the Global Network of Maternal Lineages and the Peopling of the Old World....Pages 135-152
Mitochondrial DNA Variation in the Southwest Pacific....Pages 153-181
Molecular Anthropology....Pages 183-200
Interspersed Repeat Insertion Polymorphisms for Studies of Human Molecular Anthropology....Pages 201-212
Worldwide Distribution of a Polymorphic Alu Insertion in the Progesterone Receptor Gene....Pages 213-222
Statistical Issues Regarding the Use of Microsatellite Loci for Molecular Anthropological Studies....Pages 223-235
Epilogue....Pages 237-239
Back Matter....Pages 241-246

✦ Subjects

Anthropology; Evolutionary Biology; Human Genetics