## Abstract Analysis of recurrent DNA amplification can lead to the identification of cancer driver genes, but this process is often hampered by the low resolution of existing copy number analysis platforms. Fiftyβone breast tumors were profiled for copy number alterations (CNAs) with the highβreso
Genomic copy number alterations in cancer: high-resolution analysis of the NCI-60 panel
β Scribed by D. Rico; J. Earl; R. Diaz-Uriarte; O.M. Rueda; G. Marenne; G. Pita
- Publisher
- Elsevier
- Year
- 2010
- Tongue
- English
- Weight
- 63 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1871-6784
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Recurrent cancer genome aberrations are indicators of residing crucial cancer genes. Although recent advances in genomic technologies have led to a global view of cancer genome aberrations, the identification of target genes and biomarkers from the aberrant loci remains difficult. To facilitate sear
## Abstract Highβresolution techniques for analysis of genome copy number (CN) enable the analysis of complex cancer somatic genetics. However, the analysis of these data is difficult, and failure to consider a number of issues in depth may result in false leads or unnecessary rejection of true pos
## Abstract Cervical cancer is the second most common malignancy in women worldwide, with high risk subtypes of human papillomavirus (HPV) constituting the major etiological agent. However, only a small percentage of women infected by the virus develop disease, suggesting that additional host genet
## Abstract A multiplatform approach, including conventional cytogenetic techniques, BAC array comparative genomic hybridization, and Affymetrix 500K SNP arrays, was applied to the study of the tumor genomes of 25 follicular lymphoma biopsy samples with paired normal DNA samples to characterize bal
## Abstract Neurofibromatosis Type I (NF1) is an autosomal dominant disorder characterized by the development of both benign and malignant tumors. The lifetime risk for developing a malignant peripheral nerve sheath tumor (MPNST) in NF1 patients is βΌ10% with poor survival rates. To date, the molecu