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Genomic characterization of the chromosomal breakpoints of t(4;14) of multiple myeloma suggests more than one possible aetiological mechanism

โœ Scribed by Fenton, James A L; Pratt, Guy; Rawstron, Andy C; Sibley, Kathryn; Rothwell, Dominic; Yates, Zoe; Dring, Ann; Richards, Steve J; Ashcroft, A John; Davies, Faith E

Book ID
110067450
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
210 KB
Volume
22
Category
Article
ISSN
0950-9232

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Translocation t(11;14) in multiple myelo
Translocation t(11;14) in multiple myeloma: Analysis of translocation breakpoints on der(11) and der(14) chromosomes suggests complex molecular mechanisms of recombination
โœ James A. L. Fenton; Guy Pratt; Dominic G. Rothwell; Andy C. Rawstron; Gareth J. ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 141 KB ๐Ÿ‘ 1 views

## Abstract We describe the characterization of the genomic DNA breakpoints of two multiple myeloma (MM) patients with t(11;14). __IGH__ translocation events are present in many MM tumors, and it is proposed that they occur early in the pathogenesis, based on the assumption that the translocations