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Genomic characterization of hepatitis C virus isolates from Argentina

✍ Scribed by Dr. José Raúl Oubiña; Jorge Fabián Quarleri; Marcelo Rudzinski; Carlos Parks; Isabel Badía; Stella Maris González Cappa

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
790 KB
Volume
47
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Thirty‐three Argentinian patients infected with hepatitis C virus (HCV) were studied for viral genotyping. The patients included 10 hemophiliac and 4 polytransfused children and 19 adults: 3 polytransfused, 7 dialyzed and 9 sporadic cases. Core‐based genotyping permitted the classification of 31 samples. Genotypes II, I and V were the most frequent: 21 (63.6%), 16 (48.4%) and 10 (30.3%) of the 33 patients, respectively. Only one polytransfused patient carried genotype IV. Genotype II was detected in 7 out of 9 sporadic cases. Thirteen patients (39.3%) were coinfected with two genotypes, and 2 others were coinfected with three genotypes. The remaining 2 samples which could not be typed were characterized following the restriction fragment length polymorphism (RFLP) method, and were classified as type 1. One of these had two consecutive transitional mutations in the 5′ untranslated region (5′ UTR). © 1995 Wiley‐Liss, Inc.

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