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Genomic and nongenomic effects of aldosterone in the rat heart: why is spironolactone cardioprotective?

✍ Scribed by Wenxia Chai; Ingrid M Garrelds; Udayasankar Arulmani; Regien G Schoemaker; Jos M J Lamers; A H Jan Danser


Book ID
110008732
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
187 KB
Volume
145
Category
Article
ISSN
0007-1188

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## Abstract ## Background The effects of two drugs representing different classes of antidiabetic pharmacology (pioglitazone, a thiazolidinedione; and metformin, a biguanide) on the myocardial metabolism in the ischemia are poorly understood. ## Methods To test the hypothesis that cardioprotecti