Genomewide genetic association studies in hepatology: The end of searching for the needle in the haystack?

✍ Scribed by Claus Hellerbrand; Hermann E. Wasmuth

• Book ID: 102238803
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 268 KB
• Volume: 46
• Category: Article
• ISSN: 0270-9139
• DOI: 10.1002/hep.22054

✦ Synopsis

results imply an important role for BMP7 at multiple levels in the fibrotic process.

Recent knowledge discussed above suggests the universality of cell plasticity and mutes the concept of terminal differentiation. Potential therapies arising from this work include exploiting BMP7, endoglin, 13 and the CBF-A signal. Although the HSC liver fibrosis paradigm has a firm basis, the roles of other cell types including the hepatocyte is being revisited. Emerging from this endeavor are indications that fibrosis is of greater cellular and molecular complexity than previously thought.