𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genome-wide studies in pharmacogenomics: harnessing the power of extreme phenotypes

✍ Scribed by Gurwitz, David; McLeod, Howard L


Book ID
121189815
Publisher
Future Medicine
Year
2013
Tongue
English
Weight
821 KB
Volume
14
Category
Article
ISSN
1462-2416

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Genome-wide pleiotropy of osteoporosis-r
✍ David Karasik; Yi-Hsiang Hsu; Yanhua Zhou; L Adrienne Cupples; Douglas P Kiel; S πŸ“‚ Article πŸ“… 2010 πŸ› American Society for Bone and Mineral Research 🌐 English βš– 158 KB

## Abstract Genome‐wide association studies offer an unbiased approach to identify new candidate genes for osteoporosis. We examined the Affymetrix 500K + 50K SNP GeneChip marker sets for associations with multiple osteoporosis‐related traits at various skeletal sites, including bone mineral densit

Power of genome-wide association studies
✍ Joseph Pickrell; FranΓ§oise Clerget-Darpoux; Catherine Bourgain πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 336 KB πŸ‘ 2 views

## Abstract Though multiple interacting loci are likely involved in the etiology of complex diseases, early genome‐wide association studies (GWAS) have depended on the detection of the marginal effects of each locus. Here, we evaluate the power of GWAS in the presence of two linked and potentially

Improving power in genome-wide associati
✍ Kathryn Roeder; B. Devlin; Larry Wasserman πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 167 KB πŸ‘ 2 views

## Abstract The potential of genome‐wide association analysis can only be realized when they have power to detect signals despite the detrimental effect of multiple testing on power. We develop a weighted multiple testing procedure that facilitates the input of prior information in the form of grou