## Abstract The two breast cancer genes __BRCA1__ and __BRCA2__ were identified more than 10 years ago and, depending on population, mutations in these genes are responsible for a varying percentage of familial breast cancer. In more than half the families, the increased risk of breast cancer canno
Genome-wide search for breast cancer linkage in large Icelandic non-BRCA1/2 families
✍ Scribed by Adalgeir Arason, Haukur Gunnarsson, Gudrun Johannesdottir…
- Book ID
- 120699027
- Publisher
- BioMed Central
- Year
- 2010
- Tongue
- English
- Weight
- 932 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr2608
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Breast cancer accounts for over 20% of all female cancers. A positive family history remains one of the most important risk factors for the disease, with first‐degree relatives of patients having a twofold elevated risk. Known breast cancer susceptibility genes such as __BRCA1__ and __B
The presence of genomic rearrangements of the BRCA1 gene in breast and/or ovarian cancer families has been intensively investigated in patients from various countries over the last years. A number of different rearrangements have been reported by several studies that clearly document the involvement