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Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs

✍ Scribed by Akio Ooyama; Yoshihiro Okayama; Teiji Takechi; Yoshikazu Sugimoto; Toshinori Oka; Masakazu Fukushima

Book ID: 108583839
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 190 KB
Volume: 98
Category: Article
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2007.00424.x

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## Background: In the past 4 years, the weekly 24-hour infusion of high dose 5-fluorouracil (5-fu) and leucovorin in the treatment of patients with advanced gastric carcinoma has been prospectively studied at the authors' institution. this has enabled them to explore the possibility that the level