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Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice

✍ Scribed by Lund, Anders H.; Turner, Geoffrey; Trubetskoy, Alla; Verhoeven, Els; Wientjens, Ellen; Hulsman, Danielle; Russell, Robert; DePinho, Ronald A.; Lenz, Jack; van Lohuizen, Maarten

Book ID
118676036
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
406 KB
Volume
32
Category
Article
ISSN
1061-4036

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## Abstract A subpopulation of the CF‐1 mouse strain is sensitive to neurotoxicity following exposure to avermectins, a family of structurally related antiparasitic agents. This unusual sensitivity is the result of a deficiency in the mdr1a P‐glycoprotein that normally contributes to a functional b