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Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

โœ Scribed by Mikkelsen, Tarjei S.; Ku, Manching; Jaffe, David B.; Issac, Biju; Lieberman, Erez; Giannoukos, Georgia; Alvarez, Pablo; Brockman, William; Kim, Tae-Kyung; Koche, Richard P.


Book ID
109896820
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
577 KB
Volume
448
Category
Article
ISSN
0028-0836

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Genome-wide maps of chromatin state in p
โœ Mikkelsen, Tarjei S.; Ku, Manching; Jaffe, David B.; Issac, Biju; Lieberman, Ere ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Nature Publishing Group ๐ŸŒ English โš– 577 KB

We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse embryonic