Genome-wide Linkage Scan Reveals Three Putative Breast-Cancer-Susceptibility Loci
✍ Scribed by Juan Manuel Rosa-Rosa; Guillermo Pita; Miguel Urioste; Gemma Llort; Joan Brunet; Conxi Lázaro; Ignacio Blanco; Teresa Ramón y Cajal; Orland Díez; Miguel de la Hoya; Trinidad Caldés; Maria-Isabel Tejada; Anna González-Neira; Javier Benítez
- Book ID
- 113422587
- Publisher
- American Society of Human Genetics
- Year
- 2009
- Tongue
- English
- Weight
- 272 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0002-9297
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract We studied the feasibility of a novel approach to localize breast cancer susceptibility genes, using a low‐density genome‐wide panel of single‐nucleotide polymorphisms and taking advantage of large regions of linkage disequilibrium (LD) flanking Jewish disease genes in high‐risk cases.
## Abstract The two breast cancer genes __BRCA1__ and __BRCA2__ were identified more than 10 years ago and, depending on population, mutations in these genes are responsible for a varying percentage of familial breast cancer. In more than half the families, the increased risk of breast cancer canno
## Abstract Breast cancer accounts for over 20% of all female cancers. A positive family history remains one of the most important risk factors for the disease, with first‐degree relatives of patients having a twofold elevated risk. Known breast cancer susceptibility genes such as __BRCA1__ and __B
## Abstract Mutations in known breast cancer susceptibility genes account for a minority of the familial aggregation of the disease. To search for further breast cancer susceptibility genes, we performed a combined analysis of four genome‐wide linkage screens, which included a total of 149 multiple