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Genome-wide Linkage Analysis Identifies α-Actinin-2 as a Causative Gene in Familial Hypertrophic Cardiomyopathy

✍ Scribed by Christine Chiu; Joanne M. Lind; Richard D. Bagnall; Jodie Ingles; Laura Yeates; Marina Kennerson; Mika Jormakka; Jennifer A. Donald; Christopher Semsarian

Book ID: 119256139
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 61 KB
Volume: 18
Category: Article
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2009.05.007

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## Abstract Breast cancer accounts for over 20% of all female cancers. A positive family history remains one of the most important risk factors for the disease, with first‐degree relatives of patients having a twofold elevated risk. Known breast cancer susceptibility genes such as __BRCA1__ and __B