Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

✍ Scribed by Alic, N.; Andrews, T. D.; Giannakou, M. E.; Papatheodorou, I.; Slack, C.; Hoddinott, M. P.; Cocheme, H. M.; Schuster, E. F.; Thornton, J. M.; Partridge, L.

• Book ID: 121403888
• Publisher: Nature Publishing Group
• Year: 2011
• Tongue: English
• Weight: 830 KB
• Volume: 7
• Category: Article
• ISSN: 1744-4292
• DOI: 10.1038/msb.2011.36

✦ Synopsis

Over 700 direct transcriptional targets of the dFOXO transcription factor are identified in the adult fruit fly. dFOXO-bound genes are conserved between worm and fly, but dFOXO is not the sole mediator of the transcriptional response to changes in insulin signalling in the fly.