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Genome-Wide Association Study of Alcohol Dependence Implicates a Region on Chromosome 11

✍ Scribed by Howard J. Edenberg; Daniel L. Koller; Xiaoling Xuei; Leah Wetherill; Jeanette N. McClintick; Laura Almasy; Laura J. Bierut; Kathleen K. Bucholz; Alison Goate; Fazil Aliev; Danielle Dick; Victor Hesselbrock; Anthony Hinrichs; John Kramer; Sam Kuperman; John I. Nurnberger Jr; John P. Rice; Marc A. Schuckit; Robert Taylor; B. Todd Webb; Jay A. Tischfield; Bernice Porjesz; Tatiana Foroud

Book ID: 109124519
Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 338 KB
Volume: 34
Category: Article
ISSN: 0145-6008
DOI: 10.1111/j.1530-0277.2010.01156.x

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## Abstract A central issue in genome‐wide association (GWA) studies is assessing statistical significance while adjusting for multiple hypothesis testing. An equally important question is the statistical efficiency of the GWA design as compared to the traditional sequential approach in which genom