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Genome-wide association studies of hematologic phenotypes: a window into human hematopoiesis

✍ Scribed by Sankaran, Vijay G; Orkin, Stuart H

Book ID
120231818
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
408 KB
Volume
23
Category
Article
ISSN
0959-437X

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## Abstract We propose optimized two‐stage designs for genome‐wide case‐control association studies, using a hypothesis testing paradigm. To save genotyping costs, the complete marker set is genotyped in a sub‐sample only (stage I). On stage II, the most promising markers are then genotyped in the