Recently, genome-wide association studies have substantially expanded our knowledge about genetic variants that influence the susceptibility to complex diseases. Although standard statistical tests for each single-nucleotide polymorphism (SNP) separately are able to capture main genetic effects, dif
Genome-wide association studies in ADHD
β Scribed by Barbara Franke; Benjamin M. Neale; Stephen V. Faraone
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 463 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
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Genome wide association studies (GWAS) have revealed many fascinating insights into complex diseases even from simple, single-marker statistical tests. Most of these tests are designed for testing of associations between a phenotype and an autosomal genotype and are therefore not applicable to X chr
## Abstract Genomeβwide association studies of discrete traits generally use simple methods of analysis based on Ο^2^ tests for contingency tables or logistic regression, at least for an initial scan of the entire genome. Nevertheless, more power might be obtained by using various methods that anal
## Abstract Over the last few years, many new genetic associations have been identified by genomeβwide association studies (GWAS). There are potentially many uses of these identified variants: a better understanding of disease etiology, personalized medicine, new leads for studying underlying biolo