Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes

On the follow-up of genome-wide associat

On the follow-up of genome-wide association studies: an overall test for the most promising SNPs

✍ Peter J. Lipman; Michael H. Cho; Per Bakke; Amund Gulsvik; Xiangyang Kong; David 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 174 KB

Even in large-scale genome-wide association studies (GWASs), only a fraction of the true associations are detected at the genome-wide significance level. When few or no associations reach the significance threshold, one strategy is to follow up on the most promising candidates, i.e. the single nucle