Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: Different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type
✍ Scribed by Yasuhiro Nakashima; Hiroyuki Tagawa; Ritsuro Suzuki; Sivasundaram Karnan; Kennosuke Karube; Koichi Ohshima; Koichiro Muta; Hajime Nawata; Yasuo Morishima; Shigeo Nakamura; Masao Seto
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 384 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Abstract
Natural killer (NK) cell lymphomas/leukemias are highly aggressive lymphoid malignancies, but little is known about their genomic alterations, and thus there is an urgent need for identification and analysis of NK cell lymphomas/leukemias. Recently, we developed our own array‐based comparative genomic hybridization (array CGH) with an average resolution of 1.3 Mb. We performed an array CGH analysis for 27 NK‐cell lymphoma/leukemia cases that were classified into two disease groups based on the World Health Organization Classification (10 aggressive NK‐cell leukemia cases and 17 extranodal NK/T‐cell [NK/T] lymphomas, nasal type). We identified the differences in the genomic alteration patterns of the two groups. The recurrent regions characteristic of the aggressive NK‐cell leukemia group compared with those of the extranodal NK/T lymphoma, nasal‐type group, were gain of 1q and loss of 7p15.1‐p22.3 and 17p13.1. In particular, gain of 1q23.1‐24.2 (P = 0.041) and 1q31.3‐q44 (P = 0.003–0.047), and loss of 7p15.1‐p22.3 (P = 0.012–0.041) and 17p13.1 (P = 0.012) occurred significantly more frequently in the former than in the latter group. Recurrent regions characteristic of the extranodal NK/T lymphoma, nasal‐type group, compared with those of the other group were gain of 2q, and loss of 6q16.1‐q27, 11q22.3‐q23.3, 5p14.1‐p14.3, 5q34‐q35.3, 1p36.23‐p36.33, 2p16.1‐p16.3, 4q12, and 4q31.3‐q32.1. Our results can be expected to provide further insights into the genetic basis of lymphomagenesis and the clinicopathologic features of NK‐cell lymphomas/leukemias. © 2005 Wiley‐Liss, Inc.