Genome Stability. From Virus to Human Application

✍ Scribed by Igor Kovalchuk, Olga Kovalchuk

• Publisher: Academic Press
• Year: 2016
• Tongue: English
• Leaves: 659
• Series: Translational Epigenetics
• Edition: 1
• Category: Library

✦ Synopsis

Genome Stability: From Virus to Human Application covers the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, with the latter including major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, as well as changes in genome stability in response to aging.

Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species.

This book teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. The book also covers how epigenetic factors contribute to genome stability and how species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner.

• Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects
• Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability
• Contains applications of genome instability and its effect on human diseases
• Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

✦ Table of Contents

Content:
Translational Epigenetics Series,Front Matter,Copyright,List of Contributors,IntroductionEntitled to full textChapter 1 - Genome Stability: An Evolutionary Perspective, Pages 1-18, I. Kovalchuk
Chapter 2 - Genetic Instability of RNA Viruses, Pages 21-35, J.N. Barr, R. Fearns
Chapter 3 - Genome Instability in DNA Viruses, Pages 37-47, R. Sanjuán, M. Pereira-Gómez, J. Risso
Chapter 4 - Genome Instability in Bacteria and Archaea: Strategies for Maintaining Genome Stability, Pages 51-67, J.-E. Messling, A.B. Williams
Chapter 5 - Genome Instability in Bacteria: Causes and Consequences, Pages 69-85, A.B. Williams
Chapter 6 - CRISPR: Bacteria Immune System, Pages 87-98, A. Golubov
Chapter 7 - From Micronucleus to Macronucleus: Programmed DNA Rearrangement Processes in Ciliates Are Regulated Epigenetically by Small and Long Noncoding RNA Molecules, Pages 101-115, F. Jönsson
Chapter 8 - Homologous Recombination and Nonhomologous End-Joining Repair in Yeast, Pages 117-135, R.E. Jones, T.C. Humphrey
Chapter 9 - Meiotic and Mitotic Recombination: First in Flies, Pages 139-154, J.K. Holsclaw, T. Hatkevich, J. Sekelsky
Chapter 10 - Genome Stability in Drosophila: Mismatch Repair and Genome Stability, Pages 155-161, T. Negishi
Chapter 11 - Genome Stability in Caenorhabditis elegans, Pages 163-186, M. Rieckher, A.F.C. Lopes, B. Schumacher
Chapter 12 - Genetic Engineering of Plants Using Zn Fingers, TALENs, and CRISPRs, Pages 187-201, A. Bilichak, F. Eudes
Chapter 13 - Plant Genome Stability: General Mechanisms, Pages 203-223, A. Bilichak
Chapter 14 - Cell-Cycle Control and DNA-Damage Signaling in Mammals, Pages 227-242, V. Gomez, A. Hergovich
Chapter 15 - The Role of p53/p21/p16 in DNA-Damage Signaling and DNA Repair, Pages 243-256, Y. Kulaberoglu, R. Gundogdu, A. Hergovich
Chapter 16 - Roles of RAD18 in DNA Replication and Postreplication Repair, Pages 257-273, C. Vaziri, S. Tateishi, E. Mutter-Rottmayer, Y. Gao
Chapter 17 - Base Excision Repair and Nucleotide Excision Repair, Pages 275-302, T. Izumi, I. Mellon
Chapter 18 - DNA Mismatch Repair in Mammals, Pages 303-319, M. Yang, P. Hsieh
Chapter 19 - Repair of Double-Strand Breaks by Nonhomologous End Joining: Its Components and Their Function, Pages 321-336, P. Moskwa
Chapter 20 - Double-Strand Break Repair: Homologous Recombination in Mammalian Cells, Pages 337-351, C. Gelot, T. Le-Guen, S. Ragu, B.S. Lopez
Chapter 21 - Telomere Maintenance and Genome Stability, Pages 353-371, W. Hernandez-Sanchez, M. Xu, D.J. Taylor
Chapter 22 - The Relationship Between Checkpoint Adaptation and Mitotic Catastrophe in Genomic Changes in Cancer Cells, Pages 373-389, L.H. Swift, R.M. Golsteyn
Chapter 23 - Chromatin, Nuclear Organization, and Genome Stability in Mammals, Pages 391-407, L. Boteva, N. Gilbert
Chapter 24 - Role of DNA Methylation in Genome Stability, Pages 409-424, D. Zhou, K.D. Robertson
Chapter 25 - Noncoding RNAs in Genome Integrity, Pages 425-443, I. Kovalchuk
Chapter 26 - Human Diseases Associated With Genome Instability, Pages 447-462, B.C. Feltes, J. de Faria Poloni, K.N. Miyamoto, D. Bonatto
Chapter 27 - Cancer and Genomic Instability, Pages 463-486, W. Wei, Y. Cheng, B. Wang
Chapter 28 - Chromatin Modifications in DNA Repair and Cancer, Pages 487-509, M. Renaud-Young, K. Riabowol, J. Cobb
Chapter 29 - Genomic Instability and Aging: Causes and Consequences, Pages 511-525, C. Sidler
Chapter 30 - Nucleolar Contributions to DNA-Damage Response and Genomic (In)Stability in the Nervous System, Pages 527-539, M. Hetman
Chapter 31 - Diet and Nutrition, Pages 543-554, L.R. Ferguson
Chapter 32 - Chemical Carcinogens and Their Effect on Genome and Epigenome Stability, Pages 555-567, O. Kovalchuk
Chapter 33 - Environmental Sources of Ionizing Radiation and Their Health Consequences, Pages 569-581, A.A. Goodarzi, A. Anikin, D.D. Pearson
Chapter 34 - Sins of Fathers Through a Scientific Lens: Transgenerational Effects, Pages 585-599, M. Merrifield, O. Kovalchuk
Chapter 35 - Genomic Instability and the Spectrum of Response to Low Radiation Doses, Pages 601-614, C. Mothersill, C. Seymour
Chapter 36 - Transgenerational Genome Instability in Plants, Pages 615-633, I. Kovalchuk
Chapter 37 - Methods for the Detection of DNA Damage, Pages 635-649, D.V. Firsanov, L.V. Solovjeva, V.M. Mikhailov, M.P. Svetlova
Chapter 38 - Conserved and Divergent Features of DNA Repair: Future Perspectives in Genome Instability Research, Pages 651-666, I. Kovalchuk
Index, Pages 667-690

✦ Subjects

Genomics;Genomes