✦ LIBER ✦
Genome scanning for complex disease genes using the transmission/disequilibrium test and haplotype-based haplotype relative risk
✍ Scribed by Dr. Tara Cox Matise
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 294 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
✦ Synopsis
Two tests for allelic association were applied to a simulated complex disease for the Genetic Analysis Workshop 9. The transmission/disequilibrium test [Spielman et al., 19931 and the haplotype-based haplotype relative risk approach [Terwilliger and Ott, 19921 were used to detect disease-associated alleles in a set of 360 computer-simuiated markers located on six chromosomes and genotyped in 200 nuclear families. This analysis emulates a genome-based search for linked markers. Computer simulations were also performed to clarify statistical properties of the TDT.