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Genome-scale models of microbial cells: evaluating the consequences of constraints

✍ Scribed by Price, Nathan D.; Reed, Jennifer L.; Palsson, Bernhard Ø.

Book ID: 118676315
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 234 KB
Volume: 2
Category: Article
ISSN: 1740-1526
DOI: 10.1038/nrmicro1023

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## Abstract Genome‐scale models have developed into a vital tool for rational metabolic engineering. These models balance cofactors and energetic requirements and determine biosynthetic precursor availability in response to environmental and genetic perturbations. In particular, allocation of addit