Genome-independent effects of 1,25-dihydroxy vitamin D-3 on membrane potential
✍ Scribed by A. Edelman; C.L. Thil; M. Garabédian; T. Anagnostopoulos; S. Balsan
- Book ID
- 115726129
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 289 KB
- Volume
- 732
- Category
- Article
- ISSN
- 0005-2736
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1a,25-dihydroxy vitamin D3 has a major role in the regulation of the bone metabolism as it promotes the expression of key bone-related proteins in osteoblastic cells. In recent years it has become increasingly evident that in addition to its well-established genomic actions, 1a,25-dihydroxy vitamin
## Abstract 1α,25‐dihydroxy vitamin D~3~ (vitamin D~3~) has an important role during osteoblast differentiation as it directly modulates the expression of key bone‐related genes. Vitamin D~3~ binds to the vitamin D~3~ receptor (VDR), a member of the superfamily of nuclear receptors, which in turn i