✦ LIBER ✦

Genome and antigenic analysis of influenza A (H3N2) viruses isolated from an epidemic in a closed community of Carmelite nuns

✍ Scribed by Dr. I. Donatelli; A. M. Takhonova; A. I. Klimov; Y. Z. Ghendon; J. S. Oxford

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 766 KB
Volume: 31
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890310208

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Eighteen influenza A (H3N2) viruses were isolated during a single outbreak in a closed community of Carmelite nuns. Serological analysis of the virus haemagglutinin (HAs), using a panel of monoclonal antibodies, demonstrated antigenic microheterogeneity. In contrast, no significant biochemical differences were detected in viral genes by RNA:RNA hybridisation or in structural or nonstructural polypeptides analysed by high‐resolution polyacrylamide gel electrophoresis (PAGE) or by limited proteolysis followed by PAGE. Influenza A (H3N2) viruses isolated in the vicinity of the convent were distinguishable from each other and from the epidemic viruses isolated in the convent both antigenically and biochemically.

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