Genital changes in female guinea pigs resulting from destruction of the median eminence
✍ Scribed by Dey, F. L.
- Publisher
- John Wiley and Sons
- Year
- 1943
- Tongue
- English
- Weight
- 313 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0003-276X
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✦ Synopsis
In a recent publication (Dey, '43) the effects of various hypothalamic and hypophysial lesions upon the gonadotrophic activity of the pituitary of the female guinea pig were reported. The results of this study indicated that the median eminence might be concerned in the regulation of pituitary gonadotrophic functions, insofar as lesions that encroached upon this structure abolished estrous cycles and caused genital atrophy.
In the present report, the effects of lesions placed directly within the median eminence are presented.
METHOD
Twenty-two mature female guinea pigs were utilized in this study. Trial operations were first performed in order to determine the Horsley-Clarke coordinates upon which the median eminence of the guinea pig lay. It was found that lesions located 8 to 9 mm. anterior to the interaural line and situated at the base of the brain would cause considerable damage to the median eminence. Lesions were placed in this region in the twenty-two experimental animals. I n each animal three punctures were made in the brain, the first in the midline and the other two 1 mm. to either side of the midline. An electrode was lowered a t each point until the base 'Aided by a grant from the Committee for Research in Problems of Sex, National Research Council. 85 Received through the courtesy of the Parke, Davis & Company. Receired through the courtesy of the Scliering Corporation.