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Genistein combined polysaccharide enhances activity of docetaxel, bicalutamide and Src kinase inhibition in androgen-dependent and independent prostate cancer cell lines

✍ Scribed by Rebekah A. Burich; William S. Holland; Ruth L. Vinall; Clifford Tepper; Ralph W. DeVere White; Philip C. Mack

Book ID: 109054185
Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 347 KB
Volume: 102
Category: Article
ISSN: 1464-4096
DOI: 10.1111/j.1464-410x.2008.07826.x

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## Abstract The androgen receptor (AR) is a ligand‐dependent transcription factor belonging to the steroid hormone receptor superfamily. Under normal conditions, in the absence of a ligand, the AR is localized to the cytoplasm and is actively transported into the nucleus upon binding of androgens.