✦ LIBER ✦
Genetics of peroxisomal enzymes in the mouse: Nonlinkage ofd-amino acid oxidase locus (Dao) to catalase (Cs) andl-α-hydroxyacid oxidase (Hao-1) loci on chromosome 2
✍ Scribed by Roger S. Holmes
- Book ID
- 104784497
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 373 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0006-2928
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✦ Synopsis
An electrophoretic polymorphism of the peroxisomal enzyme D-amino acid oxidase was observed in NZC strain Mus musculus. F1 (NZC X BALB/c) mice showed a codominant allcle two-banded phenotype which is inconsistent with the dimeric subunit structure reported for this enzyme in other species. The enzyme locus (Dao) was shown to segregate independently of Hao-1, encoding the peroxisomal enzyme hydroxyacid oxidase (liver on A4 isozyme). Thus Dao is not linked to previously mapped peroxisomal enzyme loci, Hao-1 and Cs, closely localized on chromosome 2.