✦ LIBER ✦

Genetics of IDDM: Evidence for complex inheritance with HLA

✍ Scribed by Dr. Neil Risch

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 361 KB
Volume: 6
Category: Article
ISSN: 0741-0395
DOI: 10.1002/gepi.1370060127

No coin nor oath required. For personal study only.

✦ Synopsis

Analysis of the Fifth Genetic Analysis Workshop (GAWS) insulin-dependent diabetes mellitus (IDDM) data leads to the following conclusions: 1) With a maximum-likelihood affected sib pair method, there is strong evidence for linkage with HLA and no evidence for linkage with INS, Gm, or Km. 2) Susceptibility as defined by HLA genotypes is very complex. Each DR allele has a unique susceptibility, and DR3 and DR4 haplotype associations for DR 3/4 genotypes are different from those for 3/X and 4/X. 3) Risk is substantially higher in sibships with an affected father compared to those with an affected mother. This excess cannot be attributed to transmission distortion at HLA.

📜 SIMILAR VOLUMES

Evidence for complex nuclear inheritance

Evidence for complex nuclear inheritance in a pedigree with nonsyndromic deafness due to a homoplasmic mitochondrial mutation

✍ Bykhovskaya, Yelena; Shohat, Mordechai; Ehrenman, Karen; Johnson, David; Hamon, 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 25 KB 👁 2 views

The relationship between mitochondrial genotype and clinical phenotype is complicated in most instances by the heteroplasmic nature of pathogenic mitochondrial mutations. We have previously shown that maternally inherited hearing loss in a large Arab-Israeli kindred is due to the homoplasmic A1555G

Familial hyperinsulinism with nesidiobla

Familial hyperinsulinism with nesidioblastosis of the pancreas: Further evidence for autosomal recessive inheritance

✍ Moreno, Luis A. ;Turck, Dominique ;Gottrand, Frederic ;Fabre, Monique ;Manouvrie 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 452 KB 👁 2 views

Comprehensive genetic analysis of OEIS c

Comprehensive genetic analysis of OEIS complex reveals no evidence for a recurrent microdeletion or duplication

✍ Christopher N. Vlangos; Amanda Siuniak; Todd Ackley; Hans van Bokhoven; Joris Ve 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 242 KB 👁 1 views

Evidence for a unique interaction of lor

Evidence for a unique interaction of loreclezole with the GABA receptor complex

✍ Dr. Jeffry L. Vaught; AlBert Wauquier 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 536 KB

Concordance of iron storage in siblings

Concordance of iron storage in siblings with genetic hemochromatosis: Evidence for a predominantly genetic effect on iron storage

✍ Darrell H. G. Crawford; June W. Halliday; Kim M. Summers; Michael J. Bourke; Law 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 518 KB

A mixed epigenetic/genetic model for oli

A mixed epigenetic/genetic model for oligogenic inheritance of autism with a limited role forUBE3A

✍ Jiang, Yong-hui ;Sahoo, Trilochan ;Michaelis, Ron C. ;Bercovich, Dani ;Bressler, 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB 👁 1 views

## Abstract The genetic contribution to autism is often attributed to the combined effects of many loci (ten or more). This conclusion is based in part on the much lower concordance for dizygotic (DZ) than for monozygotic (MZ) twins, and is consistent with the failure to find strong evidence for li