GENETICS OF HEMOCHROMATOSIS
✍ Scribed by ROBERT DEBRÉ; JEAN-CLAUDE DREYFUS; JEAN FRÉZAL; DOMINIQUE LABIE; MAURICE LAMY; PIERRE MAROTEAUX; FANNY SCHAPIRA; GEORGES SCHAPIRA
- Book ID
- 115246738
- Publisher
- John Wiley and Sons
- Year
- 1958
- Tongue
- English
- Weight
- 815 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0003-4800
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Hemochromatosis is an autosomal recessive disease of iron metabolism, characterized by progressive iron loading in parenchymal cells of the major organs of the body. This iron overload may result in cirrhosis, diabetes, cardiac failure and arrythmia, hypogonadism, arthritis, hepatocellular carcinoma
We previously reported five families with primary, genetic (idiopathic) hemochromatosis in whom HLA typing of subjects indicated that a homozygous-heterozygous mating had almost certainly occurred and in whom inheritance of the disease trait was best explained by an autosomal recessive mode of inher