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Genetics of expression of xenotropic virus and autoimmunity in NZB mice

✍ Scribed by DATTA, SYAMAL K.; SCHWARTZ, ROBERT S.

Book ID: 109702518
Publisher: Nature Publishing Group
Year: 1976
Tongue: English
Weight: 587 KB
Volume: 263
Category: Article
ISSN: 0028-0836
DOI: 10.1038/263412b0

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## Abstract Prepubertal castration of female NZB/NZW (B/W) hybrid mice did not influence mortality, whereas prepubertal castration of male B/W mice caused premature death and enhanced autoantibody formation. Prepubertal castration combined with the administration of sustained estradiol‐17‐β (E‐2) e