Genetics of autoimmune disease

✍ Scribed by Tony R Merriman; John A Todd

• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 754 KB
• Volume: 7
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/0952-7915(95)80049-2

✦ Synopsis

In the past year, the major advances in understanding the genetics of autoimmune disease in both man and mouse have been made as a result of using the positional cloning approach. Construction of congenic mouse strains, and, in humans, the exploitation of linkage disequilibrium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.