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Genetics and physiological expression of β-hydroxy acid dehydrogenase inDrosophila

✍ Scribed by Jack E. Tobler; Ellsworth H. Grell

Publisher
Springer
Year
1978
Tongue
English
Weight
455 KB
Volume
16
Category
Article
ISSN
0006-2928

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✦ Synopsis

A mutant Hadnl was induced in Drosophila melanogaster and found to be deficient in beta-hydroxy acid dehydrogenase. This mutation was utilized to study the genetics and physiological expression of Had+ . Had+ was mapped to the X chromosome at 54.4 and seems to be the structural gene for the enzyme. Enzyme activity in male and female flies indicates that the gene shows both dosage compensation independent from dose effect and differential activity during ontogeny. Electrophoretic mobility data indicate that the enzyme is a dimer which forms by random association of subunits. The fact that the mutant shows no detrimental effect implies that the enzyme is dispensable, at least under laboratory conditions. The biological and technical implications of this gene--enzyme system are discussed.

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