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Genetics and ontogeny of aldehyde dehydrogenase isozymes in the mouse: Localization ofAhd-1 encoding the mitochondrial isozyme on chromosome 4

✍ Scribed by Roger S. Holmes

Publisher: Springer
Year: 1978
Tongue: English
Weight: 493 KB
Volume: 16
Category: Article
ISSN: 0006-2928
DOI: 10.1007/bf00484541

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✦ Synopsis

Electrophoretic variants for the mitochondrial isozyme of aldehyde dehydrogenase (AHD) have been observed in inbred strains and in Harwell linkage testing stocks of Mus musculus. F1 (LVC X C57BL/Go) mice showed a codominant allele three-bounded phenotype, which suggests a dimeric subunit structure (designated AHD-A2). The anodal-migrating supernatant isozyme of AHD was electrophoretically invariant among the 23 inbred strains and stocks examined. The genetic locus encoding AHD-A2 (suggested name Ahd-1) is localized on chromosome 4 and was mapped close to je (jerker) and Gpd-1 (encoding the liver and kidney isoenzyme of glucose-6-phosphate dehydrogenase). Ontogenetic analyses demonstrated that both AHD isozymes exhibited low activity in late fetal and early neonatal liver and kidney extracts, and reached adult levels within 3 weeks of birth.

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