๐”– Bobbio Scriptorium
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Genetically engineered HSV in the treatment of glioma: a review

โœ Scribed by James M. Markert; G. Yancey Gillespie; Ralph R. Weichselbaum; Bernard Roizman; Richard J. Whitley

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
311 KB
Volume
10
Category
Article
ISSN
1052-9276

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โœฆ Synopsis

Central nervous system malignancies, particularly glioblastoma multiforme, pose signiยฎcant problems for the development of novel therapeutics. In the absence of advances with standard surgical and chemotherapeutic approaches, the utilisation of genetically engineered viruses, both as direct oncolytic agents as well as for the delivery of foreign proteins, represents a signiยฎcant advance in the experimental approach to management of patients with these incurable tumours. Among other viruses, HSV offers an opportunity to directly inยฏuence the replication of tumour cells within the central nervous system. Because of its propensity to replicate in neuronal tissue as well as its large coding capacity, it provides an experimental model for the development of novel therapeutics. The status of these experimental approaches will be summarised in this review.

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