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Genetic variation of hepatitis B surface antigen coding region among infants with chronic hepatitis B virus infection

✍ Scribed by Omana V. Nainan; Marina L. Khristova; KwanSoo Byun; Guoliang Xia; Patricia E. Taylor; Cladd E. Stevens; Harold S. Margolis

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
88 KB
Volume
68
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Variants in the amino acid composition of the primary antibody‐binding site of hepatitis B surface antigen (HBsAg) have been identified in a number of populations with chronic hepatitis B virus (HBV) infection. Direct sequencing of amplified or cloned PCR products, solid phase detection of sequence‐specific PCR products (SP‐PCR), and limiting dilution cloning PCR (LDC‐PCR) were compared to determine their sensitivity in detecting differing concentrations of HBsAg variants. LDC‐PCR had the greatest sensitivity and could detect HBsAg variants at a concentration of 0.1% of the total viral population. HBsAg variants were detected in 51% of infants with chronic HBV infection acquired after postexposure prophylaxis, and more than half of the variants were detected only by the most sensitive methods. J. Med. Virol. 68:319–327, 2002. © 2002 Wiley‐Liss, Inc.

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