Genetic variation of 3β-hydroxysteroid dehydrogenase type II in three racial/ethnic groups: Implications for prostate cancer risk
✍ Scribed by Devgan, Sunita A.; Henderson, Brian E.; Yu, Mimi C.; Shi, Chen-Yang; Pike, Malcolm C.; Ross, Ronald K.; Reichardt, Juergen K.V.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 35 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0270-4137
No coin nor oath required. For personal study only.
✦ Synopsis
Background:
Elevated prostatic dihydrotestosterone (dht) has been suggested to increase the risk of prostate cancer. the hsd3b2 gene encodes the type ii 3 beta-hydroxysteroid dehydrogenase: one of two enzymes that initiate the inactivation of dht. thus, the hsd3b2 gene is a candidate gene for predisposition to prostate cancer.
Methods:
We have determine the distribution of a complex dinucleotide repeat in the hsd3b2 gene in high-risk african-americans, intermediate-risk euro-americans, and low-risk asians. genomic dna from 312 individuals was amplified by polymerase chain reaction (pcr) and analyzed by electrophoresis on denaturing polyacrylamide gels.
Results:
We have found that certain alleles are either unique to or much more common in either african-americans, asians, or euro-americans. our data also substantially expand the number of alleles reported for the complex dinucleotide repeat polymorphism in the hsd3b2 gene.
Conclusions:
Our report demonstrates substantial genetic variation in the hsd3b2 gene. we hypothesize that allelic variants of the hsd3b2 gene may play a role in predisposition to prostate cancer, and in explaining the substantial racial/ethnic variation in risk.