Genetic variation in the tumor necrosis factor-α promoter region and in the stress protein hsp70-2 : Susceptibility and prognostic implications in breast carcinoma
✍ Scribed by Souhir Mestiri; Noureddine Bouaouina; Slim Ben Ahmed; Achraf Khedhaier; Besma Belhadj Jrad; Sami Remadi; Lotfi Chouchane
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 121 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND.
Tumor necrosis factor-␣ (TNF-␣) and stress proteins (heat shock proteins) are determining factors in the immune response to tumor cells. The authors designated a large study to investigate the susceptibility and prognostic implications of the genetic variation in TNF-␣ and hsp70-2 in breast carcinoma.
METHODS.
The authors used the polymerase chain reaction and restriction enzyme digestion to characterize the variation of the TNF-␣ promoter region and that of the hsp70-2 gene in 243 unrelated Tunisian patients with breast carcinoma and 174 healthy control subjects. Associations of the clinicopathologic parameters and the genetic markers with the rates of the breast carcinoma specific overall survival and the disease free survival (DFS) were assessed using univariate and multivariate analyses.