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Genetic variation in genes encoding for polymerase ζ subunits associates with breast cancer risk, tumour characteristics and survival

✍ Scribed by Verena Varadi; Melanie Bevier; Ewa Grzybowska; Robert Johansson; Kerstin Enquist; Roger Henriksson; Dorota Butkiewicz; Jolanta Pamula-Pilat; Karolina Tecza; Kari Hemminki; Per Lenner; Asta Försti

Publisher: Springer US
Year: 2011
Tongue: English
Weight: 315 KB
Volume: 129
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-011-1460-z

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## Abstract A recent candidate gene association study identified a single nucleotide polymorphism (SNP) in the __PPP2R2B__ gene (rs319217, A/G) that manifests allelic differences in the cellular responses to treatment with chemotherapeutic agents (Vazquez et al., Nat Rev Drug Discov 2008;7:979‐87).